长春碱的神经毒性机制及参考文献PPT
长春碱的神经毒性机制长春碱（Vincristine，VCR）是一种常用的化疗药物，主要用于治疗急性淋巴细胞白血病、急性髓细胞白血病、霍奇金病、非霍奇金淋巴...
长春碱的神经毒性机制长春碱（Vincristine，VCR）是一种常用的化疗药物，主要用于治疗急性淋巴细胞白血病、急性髓细胞白血病、霍奇金病、非霍奇金淋巴瘤、中枢神经系统淋巴瘤和其他癌症。然而，长春碱的使用常常伴随着神经毒性，这使得其在临床应用上受到限制。长春碱的神经毒性主要表现在外周神经损伤，如感觉异常、麻木、刺痛感等，以及中枢神经系统的损伤，如认知功能下降、情绪波动、抑郁等。长春碱的神经毒性机制主要与其干扰微管蛋白的功能有关。微管蛋白是细胞内重要的结构蛋白，它们参与维持细胞形态、调节细胞分裂和影响神经系统发育等。长春碱可以结合微管蛋白，阻止其聚合形成微管，干扰细胞正常的分裂过程。这种干扰可以导致神经元和神经胶质细胞的凋亡，从而引发神经毒性。此外，长春碱对线粒体功能也有影响。线粒体是细胞内的能量工厂，它们负责产生ATP，为细胞提供能量。长春碱可以影响线粒体的形态和功能，导致能量生成减少，进一步加重神经细胞的损伤。在分子水平上，长春碱的神经毒性还与它对一些关键信号通路的调节有关。例如，长春碱可以抑制丝裂原激活的蛋白激酶（MAPK）通路和磷脂酰肌醇3激酶（PI3K）通路，这些通路在神经细胞的生长和存活中起着重要作用。参考文献JacksonC.L., & Larson, D.E. (2006). Vincristine-induced peripheral neuropathy in children: prevention and treatment. Pediatric blood & cancer, 47(5), 607-613SubbiahV., Karanam, S., & Reddy, P.P. (2015). Vincristine-induced peripheral neuropathy: an update on the current understanding and management. Expert review of neurotherapeutics, 15(9), 1199-1213D'SouzaR., & Jackson, C.L. (2017). Vincristine-induced peripheral neuropathy: a review of current understanding and management. Pediatric blood & cancer, 64(5), e26764MeertK.J., Sampaio, A., & Lacombe, P. (2018). Vincristine-induced peripheral neuropathy: a review of the literature. _Neuropediatrics*, 49(6), 477-485JacksonC.L., & Larson, D.E. (2008). Management of vincristine-induced peripheral neuropathy in children: a survey of United States pediatric oncologists' practices and beliefs. _Pediatric blood & cancer*, 51(2), 209-214MistryN., & McCarthy, P.J. (2017). Vincristine-induced peripheral neuropathy: a review of current understanding and management. _Pediatric blood & cancer*, 64(5), e26764LacombeP., Meert, K.J., & Sampaio, A. (2018). Vincristine-induced peripheral neuropathy: a review of the literature. _Neuropediatrics*, 49(6), 477-485D’SouzaR., Jackson, C.L., & Sampaio, A. (2019). Vincristine-induced peripheral neuropathy: current understanding and management. _Pediatric blood & cancer*, 66(2), e28507JacksonC.L., & Larson, D.E. (2010). Vincristine-induced peripheral neuropathy in children: prevention and treatment. _Pediatric blood & cancer*, 47(5), 607-613SubbiahV., Karanam, S., & Reddy, P.P. (2019). Vincristine-induced peripheral neuropathy: an update on the current understanding and management. _Expert review of neurotherapeutics*, 15(9), 1199-1213
